Pyroluria treatment

Pyroluria is a condition where the body manufactures excess pyrroles. These chemicals are a byproduct produced when the body makes hemoglobin for red blood cells and they have no purpose in your body. They are usually removed out of the body through urine. People with pyroluria are unable to effectively get rid of pyrroles and as a result they accumulate in their body 1, 3.

When we talk of a pyrrole, it is a chemical substance found in the body which is involved in the process of making heme, the substance that makes blood to be red in color. When pyrroles bind with zinc and vitamin B6, they deplete these nutrients in the body. Pyroluria happens when pyrroles attach to zinc and Vitamin B6 or pyroxidine. This binding causes large quantities of vitamin B6 and zinc to be flushed out of the body.

As a result, it leads to low quantities of these vital nutrients in the body, which can eventually cause Vitamin B6 and Zinc deficiency, respectively. Vitamin B6 helps in the metabolism of amino acids, carbohydrates, lipids, heme and nucleic acid. There are compounds that are closely related to vitamin B6 such as pyridoxamine, pyridoxine and pyridoxal.

These compounds are broken down in the body to form pyridoxal phosphate, which acts like a coenzyme in skin metaboliziation and blood reaction 5. Zinc is a vital mineral needed in your body to support manufacture of cells and fight infections. It is required in sexual development and reproduction. When large amounts of zinc are excreted through your urine, it leads to zinc deficiency. Zinc deficiency affects your body to produce healthy cells 6. Zinc deficiency can affect your immune system.

Inadequate zinc levels also delays sexual development as well as make men impotent. There are a number of factors that can elevate your risk for pyroluria.

They include 2 :. There are many signs and symptoms associated with pyroluria. They include 1, 4 :. Pyroluria is diagnosed through kryptopyrroles urine test. Your doctor will tell you to collect your urine and take it to the laboratory for analysis.

During the analysis, your doctor will determine the amount of kryptopyrroles in your urine. Your doctor will discuss with you the test results 1. This means that you have pyroluria. If your doctor suspects you have zinc deficiency, blood tests will be ordered.

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Your doctor will collect a sample of your blood and analyze it for the amount of zinc present.What is pyroluria? Pyroluria pyrrole disorder, kryptopyrrole, kryptopyrroluria, pyrroluria, mauve factor or hemepyrrole is a common metabolic condition that occurs when pyrrol, a key component of haemoglobin, is overproduced by the liver.

It is a lifelong condition, and symptoms tend to worsen with age and chronic stress. Often people with pyroluria will suffer a variety of serious ailments and degenerative diseases for years, regardless of what therapies they try or how well they eat. It is only after diagnosis that they finally take the correct supplements and steps to manage their condition, usually with significant success. Disciplined supplementation and treatment can manage the condition to the point where there are virtually no symptoms.

Pyroluria is a metabolic condition long recognized by those who practice orthomolecular medicine and orthomolecular psychiatry. However most doctors' medical associations do not recognise it because there are no pharmaceutical drugs to treat it, and it can be completely and effectively managed with basic supplements. Don't be surprised if your doctor has not heard of pyroluria or disparages the condition. In Australia the AMA refuses to recognise the condition.

However, an increasing number of doctors are starting to take pyroluria seriously. With pyroluria, some of the by-products of the synthesis of haemoglobin called kryptopyrroles are produced in excess by the liver and not fully excreted in the urine. These kryptopyrroles more specifically hydroxyhemoppyrrolinone or HPL are normally harmless. However, if the HPL in your body builds up to an excessive level, the HPL binds to zinc and vitamin B6, and also blocks the receptor sites for these two nutrients.

The HPL-zinc-B6 complex is then excreted in the urine. The result is major deficiency in Vitamin B6 and Zinc, and to a lesser degree in other nutrients such as gamma linolenic acid GLAniacinamide, biotin, and sometimes manganese and other B-vitamins. The deficiency in zinc and B6 is so large that it cannot be counterbalanced by foods high in these two nutrients. Zinc and B6 are critical nutrients for producing all proteins including enzymes, hormones and neurotransmitters required by all organs, muscle and connective tissue.

This shortage affects the functioning of your entire body and mind, including immune system, digestion, cognitive functioning and emotions. The onset commonly occurs during a stressful event during the late teens and it continues throughout a person's life.

Pyroluria is triggered and strongly aggravated by prolonged stress such as an injury, a debilitating illness, or severe mental stress. It occurs more frequently in women than in men. Most people with pyroluria suffer from some, but not all of the symptoms listed below. A more definitive diagnosis can be done with a urine test, showing an elevated level of kryptopyrroles.

The HPL molecule is unstable and will disappear rapidly at room temperature or if exposed to bright light, so the urine to be tested may need to be chilled or transported quickly. Normal: less than 10 micrograms of HPL per decilitre. Pyroluria should not be confused with histadelia high histaminehistapenia low histamine and hypercupremia high copperwhich cause many of the same symptoms.

A study 1 led by orthomolecular psychiatrist Abram Hoffer found that pyroluria was frequently present in people with the following conditions:. Pyroluria can vary from mild borderline cases to severe.

It is often complicated by the presence of other ailments or genetic defects. Signs and symptoms will vary greatly between different individuals. Only a few of the symptoms listed below may be present in mild cases. The symptoms and conditions for each individual can vary, so a laboratory test including plasma zinc, serum copper and ceruloplasmin copper binding protein and HPL level are used to determine the patient's specific treatment needs.

In mild cases, improvement can be seen in a few days.Pyroluria is a genetically acquired chemical imbalance in which the body produces an abnormally large number of pyrroles. A pyrolle is a chemical consisting of a 5 membered aromatic ring. These chemicals are the byproduct of hemoglobin synthesis and have no known function in the body; they are normally excreted in the urine.

Most people have very few pyrroles in their system at any given time; certain individuals, however, have an unusually high number of pyrroles in their bodies, resulting in a condition known as pyroluria. Also known as Mauve Factor due to the mauve color visible on testing paper during urinalysis or pyrrole disorder, pyroluria occurs when the pyrroles bind to pyroxidine vitamin B6 and zinc, causing these vital nutrients to be excreted from the body in large amounts. Deficiencies of B6 and zinc are associated with a wide range of emotional and psychiatric problems.

Nervousness, extreme irritability, anxiety, depression, short-term memory problems, and explosive anger have all been linked to pyroluria. A large percentage of patients with psychiatric disorders such as schizophrenia exhibit high levels of pyroles; alcoholics and emotionally disturbed children also tend to have an abnormally high pyrrole count.

In addition, zinc deficiencies have been associated with a number of physiological disorders, including poor immune function, poor growth, and delayed sexual development.

Because zinc and B6 are so important to both our overall physical and mental health, identifying and treating this devastating condition is critical. Individuals with pyroluria exhibit a wide range of physical, emotional and cognitive symptoms; some common characteristics of pyrolurics are described here:.

With such a wide range of symptoms, pyroluria is frequently misdiagnosed, and therefore often treated inappropriately.

While patients exhibiting certain symptoms such as depression and anxiety often experience some degree of relief from antidepressant medications, these effects are temporary and do not resolve the underlying problem. Proper identification of pyroluria is critical to its successful treatment; individuals with the disorder often experience immediate improvement of their symptoms once a treatment plan has been implemented.

Pyroluria testing typically consists of laboratory analysis of the urine for kryptopyrroles. Metabolic testing can detect elevated pyrrole levels, a positive indicator for the disease, as well as deficiencies in certain nutrients that are necessary for brain health. Pyrolurics generally respond very well to nutritional treatments which emphasize zinc and B6 supplementation.

Many patients experience some degree of relief within several days of treatment, and most undergo substantial recovery within 3 to 6 months. However, it is important to remember that treating this disease is an ongoing, lifelong process; those who discontinue treatment typically experience a near-immediate return of their symptoms.

Is Pyroluria Real? An Unbiased Look at the Facts

Because treatment for pyroluria is nutritional, rather than pharmacological, some adjustment may be necessary to determine the correct amount of zinc and B6 supplementation on an individual basis. Pyroluria supplements also contain several other nutrients in order to provide the most effective treatment:.

The symptoms of pyroluria are frequently mistaken for signs of other illnesses; all too often, doctors prescribe medications to treat the overt symptoms without taking the time to further investigate their root cause. With the appropriate lab testing, your health care provider can determine the core problem.

Once a pyrrole disorder has been identified, you will be able to take the measures necessary to correct the problem, improving your health and your overall quality of life. We Accept:. Our functional medicine approach involves identifying core imbalances which affect the brain and body network.

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We realize that there is no separating the brain and the body. What affects the body affects your brain. Log In Sign Up. Pyroluria: How Pyrroles Affect Physical and Mental Health Pyroluria is a genetically acquired chemical imbalance in which the body produces an abnormally large number of pyrroles.

Testing and Diagnosis With such a wide range of symptoms, pyroluria is frequently misdiagnosed, and therefore often treated inappropriately. Treatment of Pyroluria Pyrolurics generally respond very well to nutritional treatments which emphasize zinc and B6 supplementation.

Pyroluria supplements also contain several other nutrients in order to provide the most effective treatment: Manganese: This vital nutrient is depleted when zinc is taken at the high levels necessary for treating pyroluria. Manganese is necessary for the metabolism of certain proteins; it is also important to joint development and neurotransmitter production.

Magnesium: Taking B6 in large amounts can deplete magnesium levels; adding magnesium can reduce irritability and hypersensitivity to light and sound. Niacinamide Vitamin B3 : This nutrient is necessary for the production of tryptophan, which in turn is necessary for the production of serotonin.

Taking niacinamide helps to speed the pyroluria recovery process. Vitamin C and Pantothenic Acid: These nutrients help to rebuild adrenal glands that have been exhausted from coping with the ongoing tension caused by pyroluria; adding them to pyroluria supplements allows patients to overcome the weakness and fatigue they often feel.Supplementing with these nutrients helps to rectify the nutritional imbalances and many of the symptoms associated with Pyroluria and Pyrrole Disorder.

An important strategy in treating Pyroluria and Pyrrole Disorder is to improve the diet and increase the amount of nutrient dense and antioxidant rich foods into the daily diet. More information on how to treat and deal with these issues are included in our Pyroluria Treatment Plans. Pyroluria and Depression. Triggers for Pyroluria. The information provided here is of a general nature intended for educational purposes only. We make no claims to diagnose, treat, prevent, alleviate or cure illnesses or diseases with any information or product stated.

With any health issue we suggest you consult your healthcare professional before undertaking any health treatment. I hope you found this article useful in providing a means for treatment of Pyroluria and Pyrrole Disorder.

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If so, please leave a comment and help others by sharing on social media. Greg is a Naturopathic Doctor and Clinical Herbalist. He is passionate about educating people on all matters of health. Qualifications: B. Sc Health Science, Adv.

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Dip Naturopathy, Adv. Dip Herbal Medicine, Adv. Dip Nutrition, Dip Remedial Massage. Read More. The material on this web site is provided for educational purposes only and is not to be used for medical advice, diagnosis or treatment.

Use of this site is subject to our terms of use and privacy policy. Powered by Shopify. Menu 0. Health Articles Podcasts Videos. Pyrrole Disorder and Pyroluria Treatment. An excessive amount of symptoms is often due to the multiple roles of Zinc, Vitamin B6 and Biotin within the body.

To make it easier we have listed the nine most common Pyroluria symptoms, we come across in clinical practice. What is Candida? The amount of Candida present in your intestinal tract is regulated and kept under control by your beneficial gut bacteria. Like all opportunistic organism, if the conditions are favorable they will proliferate and Candida is no different.

pyroluria treatment

An overgrowth of Candida can affect any part of your body causing a multitude of symptoms, illnesses and eventually disease. But for a portion of people suffering from Pyroluria they are intrinsically linked.There are lifelong symptoms associated with it that tend to worsen with age and stress. During the synthesis of hemoglobin in the body, waste products called kryptopyrroles are generated. Kryptopyrroles are normally excreted uneventfully. In those with pyroluria, kryptopyrroles bind very strongly to zinc, vitamin B6, and Omega 6.

The kryptopyrroles are then excreted in the urine, taking these 3 important nutrients with them, which is a very big problem. These nutrients are critical for the functioning of your entire body and mind, including your digestion, immune system, cognitive functioning and emotions. Symptoms of pyroluria may lead to lifelong issues with severe inner tension, ongoing anxiety, poor stress tolerance stress of any kind makes symptoms worsedigestive issues including digestion of meat, frequent colds and infections, joint pain or stiffness, acne, eczema or psoriasis, mood swings and reactivity.

The really good news is that once diagnosed, pyroluria is very manageable. The bad news is that ongoing supplementation is needed indefinitely in order for symptoms to remain manageable long term. Without appropriate supplementation symptoms tend to return again in a week or two.

Unfortunately Pyroluria falls outside the realm of mainstream medicine due to the fact that the only way to rectify the problem is by improving nutritional status, diet, digestion and stress levels. Mainstream medicine relies on drugs to suppress a symptom or relieve suffering, and this form of treatment will not work for a person who has a Pyrrole disorder.

Sadly sufferers of Pyroluria fall through the cracks and are often misdiagnosed and given medication or drugs that do nothing to rectify the underlying problem. Unfortunately these medications can lead to further deterioration of a persons health.

People with this disorder have copper toxicity. Copper is an essential trace mineral that is vitally important for both physical and mental health, as long as it is kept in proper balance. Zinc lowers copper in the body. Without it, copper builds up and depletes vitamin C, which results in frequent illness. Thyroid and Adrenal glands are extremely sensitive to copper.

It also leads to the rise of estrogen, which in large amounts, is a potent carcinogen and can cause cancer. Copper has a huge impact on children. High-copper mothers pass on excessive copper and often low zinc to the fetus through the placenta.

It is also passed through breast milk, which can cause a baby to stop nursing prematurely. Common conditions such as ear infections, skin rashes and dandruff usually involve an imbalance between copper and zinc in children. There are positive traits of high levels of copper, which include a warm, caring, sensitive, emotional nature and a child-like quality. Many traditionally feminine traits are associated with high copper levels, such as softness, gentleness and intuitiveness.

High copper people are often young looking.

pyroluria treatment

But, if copper gets too high, negative personality traits show up. Some with high copper dislike protein. They become obligatory vegetarians and crave high carbohydrate diets.

pyroluria treatment

This is because too much copper impairs liver function, which is necessary to break down protein. They are no longer able to digest meat very well. Protein feels heavy or causes other symptoms.

However, these individuals usually NEED to eat protein because red meat is the best dietary source for zinc, which lowers the levels of copper, and makes the digestive enzymes needed for the breakdown of protein. In fact, becoming vegetarian actually makes things worse because vegetarian proteins are high in copper, such as nuts, beans, seeds and grains. Once zinc is introduced, the taste for meat will come back, as will the ability to digest it.

When the body of a pyroluric individual is stressed, Vitamin B6 is excreted, thus the loss of dopamine. Unfortunately, Zinc is also dumped in this process, which is essential to blood sugar regulation by influencing carbohydrate metabolism, increasing insulin response, and improving glucose tolerance.You still have social anxiety, that inner tension that you push through and deal with, and likely still feel uncomfortable when in large groups. You force yourself to put on the confident brave face.

You may still not be a big breakfast eater and have morning nausea. You may not yet be having pleasant dreams that you always remember. If pyroluria is new to you here is the Pyroluria Questionnaire from The Antianxiety Food Solution and here is a nice summary — Pyroluria, social anxiety, introversion: a summary.

Pyrrole Disorder and Pyroluria Treatment

This checklist is a starting point to try and figure out what may be the issue. I discussed 21 of these in my interview on season 3 of the Anxiety Summit: Pyroluria, Amino Acids and Anxiety: Troubleshooting when you are not getting results. I expect this list to grow. This list is NOT in my book The Antianxiety Food Solution but the pyroluria questionnaire, protocol and testing information is my book has a whole chapter on pyroluria.

Pyrrole Disorder and Pyroluria Treatment

If you are not already registered for the Anxiety Summit you can get live access to the speakers of the day here: www. Or want this and the other great interviews for your learning library? Food Mood Expert Trudy Scott is a certified nutritionist on a mission to educate and empower anxious individuals worldwide about natural solutions for anxiety, stress and emotional eating.

Trudy is passionate about sharing the powerful food mood connection because she experienced the results first-hand, finding complete resolution of her anxiety and panic attacks.

pyroluria treatment

Trudy, what a wonderfully comprehensive list! This will be a big help for me, and many others, going forward. Thanks for sharing!

What about pyroluria and measuring kryptopyrroles?

Positively fantastic!!! Trudy, thanks so much for taking the time to reply!! The link to Dr. There is no copper in any of my supplements except a liquid mineral supplement BioPure Micro Minerals which contains all major and trace minerals and elements, so it contains a small amount of copper I take 1 tbsp per day.

I had low levels of most omega 6s, normal levels of most omega 3s, normal levels of omega 9s, and saturated fatty acids varied some low, some normal, some high. It initially tasted like water, then progressed to taste like mineral water, and now tastes like string cheese, sweet, with a mild mineral-y flavor that puts my tongue on edge like the sensation you get after eating spinach.

It definitely does not taste really bad or repulsive. My serum copper and zinc have been in normal range when tested through regular labs. I have not tested ceruloplasmin. My serum copper was 0. Before I began the pyroluria protocol, serum zinc was 0. My score on the pyroluria questionnaire is 38 out of 42 all the symptoms apply except 6, 10, 11, and 27 I scored 20 out of 23 on the introversion questionnaire all apply except 2, 11, 12 Before starting the protocol I did not have pleasant dreams and rarely remembered my dreams unless they were nightmares.

Since starting the protocol I dream most nights some pleasant, but most stressful, and some vivid nightmares still. On a scale ofmy social anxiety before was 10 and now is Pyroluria is a unique metabolic condition that is very rarely recognized in both the medical and natural health world.

Pyrolur ia is considered by many in the functional medicine world the most common unknown disorder. Pyrolurics need a specific diet, lifestyle and supplementation program to get well. When this goes undiagnosed and untreated it becomes very challenging for these individuals to ever get well despite the use of holistic therapies. Most will struggle with their health throughout their life and never find any long-term answers. The Kryptopyrrole test determines the levels of pyrroles the body excretes.

Pyrroles have little or no function in the body and are effectively excreted in the urine. However, pyrroles have an affinity for zinc and vitamin B6. So, when pyrroles are elevated in the urine they deplete the body of vitamin B6 and zinc and represent a marker for functional deficiencies in vitamin B6 and zinc.

A high incidence of pyrrole disorder is found in individuals on the autism spectrum, individuals with anxiety disorder, depression, obsessive-compulsive disorder, schizophrenia, bipolar disorder, aspergers, and ADHD. View Sample Test Here. Fortunately, because of the many thousands of newsletter readers and social media followers, my team has been able to network with a great lab distributor and get the best possible pricing for everyone.

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If the test requires blood work you can take your kit to any local lab and have the trained professional take your blood and fill out the kit and send it in the mail. Urine and blood prick tests can all be done in the comfort of your home and sent into the lab with the mailing slip in your kit.

All instructions will be sent to you with the kit. It is a very simple process that most anyone can figure out. The lab also has a customer service phone if any help is needed. Skip to content. Was this article helpful?


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